Acetyl Dipeptide-1 Cetyl ester


Acetyl Dipeptide-1 Cetyl ester (Lipo-dipeptide Tyr-Arg, with the sequence N-Acetyl-Tyrosyl-Arginyl-Hexadecyl Ester) is an active lipopeptide developed by Sederma known under the trade name Idealift™.

This lipopeptide exhibits good stimulating results on elastin production. As a result, Acetyl Dipeptide-1 Cetyl ester fights against cutaneous sagging and decreases the visible effects of gravity on the skin, which accentuates flaccid jowls due to aging or daily aggressions.

The efficacy of Lipo-dipeptide Tyr-Arg was demonstrated in vitro by measuring elastin synthesis and elastin fiber architecture. The quantity of elastin/tropoelastin settled in the extracellular matrix after release from the fibroblasts increased by more than 94%.

Idealift™ has also been shown to intervene in the various stages of elastic tissue formation and maturation. Elastic tissue consists of elastin and different proteins acting as a guide and enabling anchoring and stabilization; enzymes are also necessary for development (Fibrillin-1, fibulin-5, and lysyl oxidase in particular).

Tests were carried out on 26 female volunteers aged 54 to 75 with sagging skin. Women applied a cream containing 4% Acetyl Dipeptide-1 Cetyl ester twice a day for two months.
Effects of this new active ingredient were proven after just one month. They were confirmed using various evaluation techniques (Aeroflexmeter®, a new device developed and patented by Sederma, FOITS, and self-evaluation). As a result, the visible effects of gravity decreased, cutaneous sagging was fought, and for 80% of panelists, their skin was firmer.

This is an ideal ingredient for formulas against skin sagging that also improve resistance to gravity and firmness, helping women look younger.

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Products containing Acetyl Dipeptide-1 Cetyl ester